Unforeseen In Animal Tests

News entries 12th October to 19th November

Testing medications on animals means drug trials and drug releases littered with surprises. This isn't an occasional event, it is commonplace.

“Propoxyphene: Withdrawal - Risk of Cardiac Toxicity. Sold as Darvon, Darvocet, and generics.”
FDA Medwatch. 19 November 2010

“Heart drug Multaq linked with 387 reports of adverse effects.”
Sacramento Bee. 19 November 2010.

“Study of Pfizer, Bristol drug halted by bleeding.”
Reuters. 19 November 2010.

“Heart drug raises questions. Report links Multaq with 387 reports of adverse effects.”
JS Online. 19 November 2010

“Health Canada announces restrictions on diabetes drug due to heart risks.”
Winnipeg Free Press. 18 November 2010

“ResVerlogix cholesterol drug fails mid-stage trial.”
Reuters. 17 November 2010.

“Weight loss drug 'caused death of 500 people'.” 
Daily Telegraph. 16 November 2010.

“France: Diabetes drug may be linked to 500 deaths.”
Google. 16 November 2010.

“Major new study shows Natrecor is safe, but not very effective.”
LA Times. 14 November 2010.

“October 2010 Safety Labeling Changes.
This posting includes 34 products with safety labeling changes to the following sections: BOXED WARNINGS, CONTRAINDICATIONS, WARNINGS, PRECAUTIONS, ADVERSE REACTIONS, PATIENT PACKAGE INSERT, and MEDICATION GUIDE. The "Summary Page" provides a listing of drug names and safety labeling sections revised.”

FDA Medwatch. 13 November 2010

 “Blood-clotting drug given to wounded soldiers can cause heart attacks. Trials of NovoSeven, used to halt blood loss, suggest it is no more effective than placebo and raises risk of clots in arteries.”
The Guardian. 13 November 2010
“Acne linked to suicide risk. Acne drugs may make things worse, say scientists.”
The Guardian. 12 November 2010.

“Study on acne suicide risk fuels debate over drugs.”
Reuters. 12 November 2010.

“Lung cancer drug experiment fails.”
Huliq. 11 November 2010.
“Suicide attempts in people taking isotretinoin for acne. Are increased, but the risk is difficult to separate from the higher risk associated with the condition itself.”
BMJ 11 November 2010
“Study links painkillers to reproductive disorders.”
Reuters. 8 November 2010.

“Drugs linked to brain damage 30 years ago. MPs and campaigners predict class action after failures to mount full-scale research into warnings left millions of patients at risk.”
The Independent on Sunday. 7 November 2010.

“..the DSMB recommended that the trial be halted because mortality in the rivastigmine group (n=12, 22%) was higher than in the placebo group (n=4, 8%; p=0·07). Median duration of delirium was longer in the rivastigmine group (5·0 days, IQR 2·7—14·2) than in the placebo group (3·0 days, IQR 1·0—9·3; p=0·06).”
Effect of rivastigmine as an adjunct to usual care with haloperidol on duration of delirium and mortality in critically ill patients: a multicentre, double-blind, placebo-controlled randomised trial
The Lancet, Early Online Publication, 5 November 2010

“Haemophilia drug can damage heart - study.”
TVNZ. 4 November 2010.

 “Are YOUR pills dangerous?”
Daily Mail. 2 November 2010.
“Why the FDA Keeps Saying 'No' to Diet Pills.”
Seeking Alpha. 1 November 2010

“Novartis Officials Hid Bone Drugs' Risks, Lawyer Tells Jurors.”
Bloomberg. 1 November 2010.
 “Firm with Earth City unit is settling suits over drugs tied to suicides.”
STLToday. 30 October 2010.

“Codeine painkillers may be 'unsafe, addictive and ineffective'.”
Daily Mail. 23 October 2010.

“GnRH Agonists: Label Change - Increased Risk of Diabetes and Cardiovascular Disease (Update).”
FDA Medwatch. 22 October 2010.
“Federal prosecutors probing Glaxo diabetes pill.”
Sacramento Bee. 21 October 2010 

“More diabetes drug woe for Lilly as teplizumab fails.”
Pharma Times. 21 October 2010.

 “Women Are Dying From Hormone Therapy; Why Is Pharma Still Allowed to Push It?”
Alternet. 21 October 2010.
“September 2010 Safety Labeling Changes:  37 Medical Product Labels with changes to Warnings, Contraindications, Precautions, Adverse Reactions”
FDA Medwatch. 21 October 2010.

“FDA warns of prostate cancer drug risks.”
Reuters. 20 October 2010.
“Hormone therapy raises breast cancer deaths: study.”
Reuters. 20 October 2010.
“Drug companies lied to women about HRT risks for nine years”

Journal of the American Medical Association, 2010; 304: 1684-92 20 October 2010
“Pfizer wins HRT trial as new study knocks safety.”
Fiercepharma. 20 October 2010. 

“Eli Lilly diabetes drug fails to meet endpoint.”
Marketwatch. 20 October 2010

“Some drugs raising red flags. Illinois doctors are speaking on behalf of pharmaceutical companies, but some of the drugs they're speaking about have come under investigation.”
Chicago Tribune. 18 October 2010
“Should long-term drugs get greater scrutiny?”

Fiercepharma. 18 October 2010.

“Glaxo ready for barrage of lawsuits”
Fiercepharma. 18 October 2010.
“Experts admit swine flu jab 'may cause' deadly nerve disease.”
Daily Mail. 16 October 2010 

“FDA warns of fractures with osteoporosis drugs.”
TMC. 16 October 2010.

“Doubts over popular drug.” [reboxetine]
The Age. 15 October 2010.

“F.D.A. Issues Warning on Bone Drugs.”
New York Times. 13 October 2010.

“Boehringer Ingelheim withdraws libido drug for women”
BMJ 341:c5701 doi: 10.1136/bmj.c5701. 12 October 2010


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From Dusk 'til Dawn
An Insider's View of the Growth of the Animal Liberation Movement

© Keith Mann